FIGURE 3.

Three-dimensional model of LRP1 CR7/CR9 tandem and prediction of immunogenic peptides. A, schematic representation of the three-dimensional model of the CR7/CR9 tandem from human LRP1 cluster II. The three CR-type modules are represented by their secondary structure elements (β-strands, arrows) colored green and marked. Residues that belong to the three well exposed, immunogenic peptides P1–P3 are shown with all of their non-hydrogen atoms, color-coded as follows: green, carbon; blue, nitrogen; red, oxygen; yellow, sulfur. B, partial sequence alignment of the CR7/CR9 tandem from human LRP1 and closely related members of the LDLR family. The sequences of the P1–P3 peptides and topologically equivalent stretches in other receptors are boxed. Notice the large sequence differences, even with the most closely related member of the family, LRP1B.