FIGURE 8.

Model of Gα₁₃-dependent activation of Rgnef downstream CCK2R. 1, gastrin stimulation of CCK2 will lead to the activation of Gα₁₃ (GTP-bound form) and dissociation from Gγβ. 2, Gα₁₃ protein activation will help to recruit Rgnef to the plasma membrane where it can bind and facilitate FAK-Tyr-397 phosphorylation. 3, at later points, Gα₁₃ can facilitate activation of the Rgnef-GEF activity leading to the activation of RhoA and signaling cascade that enhances paxillin tyrosine phosphorylation and SRE promoter activity.