FIGURE 6.

Sequence comparison of human, mouse, and rat COT kinase domain. An alignment of the sequences of COT kinase from mouse, rat, and human, encompassing amino acids 66–395, is shown. The green box highlights residues that belong to the P-loop and its insert (position 132–152). Numbering is based on the human sequence (UniProt P41279). Positions with fully conserved residues are marked with an asterisk. Conservation of between groups of strongly similar and weakly similar properties are indicated with a colon or a period, respectively.