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Structural comparison of the active site pocket of C. elegans PRMT5 bound to SAH (PDB code 3UA3) and rat PRMT4 (CARM1) bound to SAH (PDB code 3B3F). The lower images depict the putative model of the enzyme active site pockets bound to its products, represented by SAH and SDMA in the case of PRMT5 or SAH and ADMA for PRMT4.
