Sequence alignment
of human PAD family members. Catalytic residues
are highlighted with red asterisks below the alignment. The sequence
alignment was generated using Clustal Omega and visualized using Espript
3.0.229 The consensus sequence is abbreviated
as follows: uppercase letters indicate identical residues, lowercase
letters indicate consensus level >0.5, “!” represents
any conserved residue of isoleucine (I) or valine (V), “$”
represents any conserved residue of leucine (L) or methionine (M),
“%” represents any conserved residue of phenylalanine
(F) or tyrosine (Y), and “#” represents any conserved
residue of asparagine (N), aspartate (D), glutamine (Q), or glutamate
(E). The relative accessibility of each residue is depicted below
the consensus motif: blue indicates accessible residues, cyan marks
intermediately accessible residues, white stands for buried residues,
and red indicates that the accessibility is not predicted.