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. 2015 Apr 29;16(5):9693–9718. doi: 10.3390/ijms16059693

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Identification of molecular functional networks and gene ontology analysis of rat’s network genes. The genes up-regulated by down-regulation of miR-22 (A); miR-125a-3p (B); let-7 family (C); miR-214 (D); and miR-320 (E) were analyzed using GeneMANIA web tool with default weighting method (i.e., weighting based to maximize connectivity between input genes). The edges are indicated based on similar gene expression across conditions (co-expression), interact in a protein-protein interaction (physical interaction), similar protein domain (shared protein domains), expression in the same tissue or gene product identified in the same cellular location, and prediction of functional relationships between genes (predicted).

Identification of molecular functional networks and gene ontology analysis of rat’s network genes. The genes up-regulated by down-regulation of miR-22 (A); miR-125a-3p (B); let-7 family (C); miR-214 (D); and miR-320 (E) were analyzed using GeneMANIA web tool with default weighting method (i.e., weighting based to maximize connectivity between input genes). The edges are indicated based on similar gene expression across conditions (co-expression), interact in a protein-protein interaction (physical interaction), similar protein domain (shared protein domains), expression in the same tissue or gene product identified in the same cellular location, and prediction of functional relationships between genes (predicted).