Table 6.
Pathways of predicted target genes for down-regulated microRNAs in Group A, Group B and Let-7 Family. n = Number of targeted genes in a specific pathway. Statistical significant was expressed in term of false discovery rate (FDR).
| KEGG ID | Pathways | Group A | Group B | Let-7 Family | |||
|---|---|---|---|---|---|---|---|
| n | * FDR | n | * FDR | n | * FDR | ||
| rno05200 | Pathways in cancer | 40 | 4.19 × 10−18 | 39 | 3.50 × 10−15 | 29 | 5.40 × 10−12 |
| rno04010 | MAPK signaling pathway | 24 | 3.01 × 10−6 | 26 | 1.20 × 10−6 | 18 | 3.84 × 10−4 |
| rno04210 | Apoptosis | 13 | 1.37 × 10−4 | 12 | 3.72 × 10−3 | 10 | 5.13 × 10−3 |
| rno04012 | ErbB signaling pathway | 10 | n.s. | 12 | 3.72 × 10−3 | 10 | 5.14 × 10−3 |
| rno04350 | TGF-β signaling pathway | 14 | 1.68 × 10−5 | 12 | 4.18 × 10−3 | 11 | 6.03 × 10−4 |
| rno04620 | Toll-like receptor signaling pathway | 13 | 2.62 × 10−4 | 12 | 6.57 × 10−3 | 9 | n.s. |
| rno04060 | Cytokine-cytokine receptor interaction | 19 | 8.69 × 10−5 | 17 | 1.13 × 10−2 | 13 | n.s. |
| rno04660 | T cell receptor signaling pathway | 13 | n.s. | 12 | n.s. | 11 | 5.46 × 10−3 |
* FDR corrections were calculated using the Benjamini-Hochberg procedure; n.s.: Statistically no significant.