Table 1.
Human studies on the association between anti-NR2A/B antibodies and cognitive dysfunction in systemic lupus erythematosus (SLE) patients.
| References | Study Type | Number of Subjects | Amino Acid Sequence Used for Immunoassays | Reported Anti-NR2A/B Values | Essential Findings |
|---|---|---|---|---|---|
| [9] | Cross-sectional | 412 SLE patients | DWEYSVWLSN | Serum optical densities; 19% of SLE patients were anti-NR2/B antibodies positive | No association between anti-NR2A/B antibody status and cognitive impairment |
| [19] | Cross-sectional | 60 SLE patients | DWEYS | Serum optical densities; 33.3% of SLE patients were anti-NR2/B antibodies positive | No association between anti-NR2A/B antibody status and cognitive impairment |
| [31] | Longitudinal (18 months) | 40 pediatric SLE patients | DWEYSVWLSN | Serum concentration (U/mL) | Association between decline in working memory and an increase in anti-NR2A/B antibodies from baseline |
| [43] | Cross-sectional | 57 SLE patients | DWEYSVWLSN | Serum optical densities; 19% of SLE patients were anti-NR2/B antibodies positive | 7 of the 31 neuropsychological tests associated with positive anti-NR2A/B antibodies |
| [44] | Longitudinal (5 years) | 65 women with SLE | DWEYS | Serum optical densities; 35% of SLE patients were anti-NR2/B antibodies positive | No association between anti-NR2A/B antibody status and cognitive impairment; No association between rise in or persistently elevated anti-NR2A/B antibodies and cognitive function over 5 years |
| [45] | Cross-sectional | 93 SLE patients | DWEYSVWLSN | Serum optical densities; 25.8% of SLE patients were anti-NR2/B antibodies positive | No association between anti-NR2A/B antibody status and cognitive impairment |
| [46] | Cross-sectional | 43 SLE patients and 27 healthy controls | DWEYSVWLSN | Serum optical densities; 14% of SLE patients and 7.4% of healthy controls were anti-NR2/B antibodies positive | No association between anti-NR2A/B antibody status and cognitive impairment |
| [47] | Cross-sectional | 133 women with SLE | DWEYSVWLSN | Not available | Association with impaired performance in attention and executive function with positive anti-NR2A/B antibodies |