Table 6.
Comparison of the basic model of NT-proBNP with models extended by an additional biomarker.
| Comparison of Models—NT-proBNP vs. NT-proBNP + Additional Biomarker: | Measure |
|---|---|
| Galectin-3 | NRI (Categorical) (95% CI): −0.0147 (−0.1356–0.1061); p-value: 0.81102 |
| NRI (Continuous) (95% CI): 0.3401 (−0.0229–0.7031); p-value: 0.06627 | |
| IDI (95% CI): 0.0534 (0.0143–0.0924); p-value: 0.00742 | |
| TNF-α | NRI (Categorical) (95% CI): −0.0417 (−0.099–0.0155); p-value: 0.15329 |
| NRI (Continuous) (95% CI): 0.0643 (−0.1991–0.3278); p-value: 0.63213 | |
| IDI (95% CI): 0.0022 (−0.0113–0.0156); p-value: 0.75434 | |
| Cardiotrophin | NRI (Categorical) (95% CI): 0.0444 (−0.0876–0.1764); p-value: 0.5093 |
| NRI (Continuous) (95% CI): 1.175 (0.8603–1.4897); p-value: 0.00000 | |
| IDI (95% CI): 0.1207 (0.0575–0.1839); p-value: 0.00018 | |
| TGF-β | NRI (Categorical) (95% CI): 0.1204 (−0.0246–0.2654); p-value: 0.10364 |
| NRI (Continuous) (95% CI): 1.2343 (0.9371–1.5315); p-value: 0.00000 | |
| IDI (95% CI): 0.2139 (0.1314–0.2965); p-value: 0.00000 | |
| Syndecan | NRI (Categorical) (95% CI): 0.1029 (−0.0302–0.236); p-value: 0.12963 |
| NRI (Continuous) (95% CI): 1.0676 (0.7499–1.3853); p-value: 0.00000 | |
| IDI (95% CI): 0.0979 (0.0417–0.1542); p-value: 0.00064 | |
| Cystatin | NRI (Categorical) (95% CI): −0.02 (−0.1089–0.0689); p-value: 0.6595 |
| NRI (Continuous) (95% CI): 1.0519 (0.7234–1.3803); p-value: 0.00000 | |
| IDI (95% CI): 0.0733 (0.0257–0.1209); p-value: 0.00253 | |
| NGAL | NRI (Categorical) (95% CI): −0.009 (−0.0984–0.0804); p-value: 0.84352 |
| NRI (Continuous) (95% CI): 0.9628 (0.5862–1.3393); p-value: 0.00000 | |
| IDI (95% CI): 0.0407 (−0.0015–0.0828); p-value: 0.05869 | |
| PIIINP | NRI (Categorical) (95% CI): 0.0204 (−0.0888–0.1297); p-value: 0.71427 |
| NRI (Continuous) (95% CI): 0.8242 (0.4631–1.1854); p-value: 0.00000 | |
| IDI (95% CI): 0.0808 (0.0333–0.1283); p-value: 0.00086 | |
| IL1R1 | NRI (Categorical) (95% CI): 0.0186 (−0.0516–0.0888); p-value: 0.60352 |
| NRI (Continuous) (95% CI): −0.0458 (−0.4257–0.3341); p-value: 0.81317 | |
| IDI (95% CI): 0.0097 (−0.0029–0.0222); p-value: 0.13103 | |
| CRP | NRI (Categorical) (95% CI): 0.0086 (−0.0747–0.0919); p-value: 0.8404 |
| NRI (Continuous) (95% CI): 0.2581 (0.0396–0.4765); p-value: 0.02058 | |
| IDI (95% CI): 0.0259 (0.0094–0.0423); p-value: 0.00206 |
TGF-β, transforming growth factor β; NT-proBNP, N-terminal pro-brain natriuretic peptide; CysC, cystatin C; NGAL, neutrophil gelatinase-associated lipocalin 2; PIIINP, collagen III N-terminal propeptide; TNF-α, tumor necrosis factor α; CT-1, cardiotrophin 1; IL1R1, interleukin 1 receptor type I; CRP, C-reactive protein.