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. 2015 May 18;16(5):11131–11177. doi: 10.3390/ijms160511131

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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Rodent Models of Abdominal Aortic Aneurysms Exhibit Significant Changes in Volume, Circumferential Cyclic Strain, and Blood Flow Velocity. (A,B) Aortic volumes increase over 28 days in (A) elastase rats and (B) AngII apoE^−/− mice. 3D B-mode renderings are shown from before (top) and after (bottom) AAA formation. Scales: (A) 10 mm and (B) 5 mm; (C,D) Circumferential cyclic strain decreases over 28 days in (C) elastase rats and (D) AngII apoE^−/− mice. M-mode tracings are shown from before (top) and after (bottom) AAA formation. Scale: depth in mm; (E,F) Mean aortic blood flow velocity decreases after 28 days. Representative velocity waveforms on long-axis PW Doppler at the site of AAAs in an (E) elastase rat and (F) AngII apoE^−/− mouse. Baseline blood velocity values are 342.1 and 461.2 mm/s, respectively. Adapted with permission from Phillips et al. [112].