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. 2015 May 18;16(5):11131–11177. doi: 10.3390/ijms160511131

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© 2015 by the authors; licensee MDPI, Basel, Switzerland.

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).

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MRI of Thromboembolic Stroke in a Rat Model. (A) Multiparametric MRI of rat brain before and after intracarotid clot embolism treated at 1 h with intra-arterial infusion of recombinant tissue plasminogen activator (rt-PA). MRA of horizontal maximum-intensity projection maps focusing on the Circle of Willis; PWI, perfusion-weighted imaging; ADC, apparent diffusion coefficient of water; T2, mapping of T2 relaxation time; (B) Coronal maximum intensity projection of TOF-MRA shows right-sided flow deficit; (C) Pictorial representation of the location of the thrombus within the cerebral arterial tree. Coronal slice from 3D T1-weighted images at level of the middle cerebral artery (MCA) origin: the EP-2104R enhanced image (E) clearly identifies the thrombus (arrow) that was not visible on the image acquired before EP-2104R injection (D). Subfigure A is reproduced with permission from Hilger et al. [152], whereas subfigures B–E are reproduced with permission from Uppal et al. [45].