Table 3.
Number of genes with chers, genes with differential expression in AAA, and chers with TFBSs.
| Transcription Factor | Genes with Chers * | Genes with Chers in both AAA and Control | Differentially Expressed Genes † | Chers with TFBS N (%) | ||||
|---|---|---|---|---|---|---|---|---|
| AAA N | Control N | N | % | AAA N | Control N | Overlap N (%) | ||
| RUNX1 | 1330 | 1491 | 147 | 5.2 | 209 | 186 | 18 (4.6) | 80.0 |
| ELF1 | 1513 | 1570 | 166 | 5.4 | 217 | 216 | 28 (6.5) | 81.3 |
| ETS2 | 1448 | 1539 | 175 | 5.9 | 201 | 215 | 30 (7.2) | 79.0 |
| STAT5 | 1490 | 1557 | 151 | 5.0 | 221 | 209 | 23 (5.3) | 79.1 |
* ChIP-enriched regions (cher) were identified as regions containing at least seven probes with a mean enrichment value that exceeded the threshold (y0) and that were separated by at least 450 bp from another cher. The threshold was defined as the top 99th quantile (top 1%) of potential chers to limit the number of false positives included in the analysis; † The genome-wide microarray-based mRNA expression data for aneurysmal and non-aneurysmal human infrarenal abdominal aorta can be obtained from the Gene Expression Omnibus (GEO) database (Series# GSE7084) [28,29], and were described in detail in a previous publication [7]. For a listing of chers and TFBS, see Tables S1 and S2, respectively. Abbreviations: AAA: abdominal aortic aneurysm; TFBS: transcription factor binding site.