Table 1.
Characteristics of female SD rats after a 12-week treatment.
| Normal Diet Group (n = 30) | High Fat Diet Group (n = 36) | |||||
|---|---|---|---|---|---|---|
| Control (n = 10) | Hypothyroid (n = 10) | Hyperthyroid (n = 10) | Control (n = 10) | Hypothyroid (n = 10) | Hyperthyroid (n = 16) | |
| Body weight change (g) | 36 ± 24 | −35 ± 8 *** | 31 ± 7 | 56 ± 24 | −42 ± 16 *** | 49 ± 17 †† |
| Body weight change (%) | 14 ± 10 | −13 ± 2 *** | 12 ± 3 | 21 ± 9 | −15 ± 5 *** | 19 ± 7 |
| Food intake/rate/day (g) | 19 | 10 | 30 | 13 | 8 | 18 |
| Calorie intake/rat/day (kcal) | 49 | 26 | 80 | 61 | 38 | 87 |
| T3 (pg/mL) | 417 ± 85 | 269 ± 74 ** | 951 ± 454 ** | 450 ± 58 | 446 ± 176 †† | 1708 ± 1447 |
| Oxidized LDL (ng/mL) | 6.1 ± 2.5 | 2.6 ± 1.3 ** | 8.8 ± 3.0 * | 6.9 ± 1.6 | 2.1 ± 1.3 *** | 9.5 ± 3.0 * |
| MDA (nmol/mL) | 1.4 ± 0.2 | 1.4 ± 0.3 | 1.0 ± 0.2 *** | 1.0 ± 0.1 ººº | 0.7 ± 0.1 ††† | 1.0 ± 0.3 |
| HNE (nmol/mL) | 0.09 ± 0.02 | 0.09 ± 0.03 | 0.12 ± 0.05 | 0.08 ± 0.02 | 0.07 ± 0.02 | 0.11 ± 0.04 |
| Triglyceride (mg/dL) | 62 ± 8 | 46 ± 4 *** | 61 ± 36 | 50 ± 12 º | 32 ± 6 ††† | 88 ± 14 |
| Cholesterol (mg/dL) | 86 ± 13 | 87 ± 14 | 69 ± 17 * | 81 ± 14 | 185 ± 23 ††† | 64 ± 13 |
| Free cholesterol (mg/dL) | 24 ± 4 | 26 ± 5 | 19 ± 6 * | 20 ± 5 | 59 ± 8 ††† | 18 ± 7 |
| Phospholipids (mg/dL) | 156 ± 15 | 120 ± 19 ** | 141 ± 21 | 139 ± 22 | 209 ± 21 ††† | 129 ± 26 |
| Free fatty acids (mmol/L) | 1.1 ± 0.2 | 0.7 ± 0.2 ** | 1.0 ± 0.3 | 0.8 ± 0.1 ºº | 0.5 ± 0.1 | 1.2 ± 0.5 |
| HDL cholesterol (mg/dL) | 44 ± 5 | 39 ± 6 | 41 ± 7 | 44 ± 5 | 66 ± 5 ††† | 40 ± 9 |
MDA: malondialdehyde; HNE: 4-hydroxynonenal; Data are presented as means ± standard deviations * p < 0.05, ** p < 0.01, *** p < 0.001 compared to appropriate control; º p < 0.05, ºº p < 0.01, ººº p < 0.001 compared to normal diet control group; †† p < 0.01, ††† p < 0.001 compared to appropriate normal diet group.