Table 2.
Multivariable associations between adiposity measures and incident diabetes: SABRE study
| Adiposity measure | Model | Europeans |
South Asians |
African Caribbeans |
|||
|---|---|---|---|---|---|---|---|
| SHR | 95% CI | SHR | 95% CI | SHR | 95% CI | ||
| In men | |||||||
| VAT | 1 | 1.74*** | 1.49, 2.03 | 1.60*** | 1.38, 1.86 | 1.72** | 1.26, 2.35 |
| 2 | 1.43* | 1.00, 2.05 | 2.18*** | 1.61, 2.96 | 1.38 | 0.71, 2.66 | |
| 3 | 1.16 | 0.77, 1.76 | 1.90*** | 1.37, 2.64 | 1.44 | 0.69, 3.02 | |
| 4 | 1.32 | 0.90, 1.94 | 1.87*** | 1.36, 2.55 | 1.35 | 0.70, 2.62 | |
| SAT | 1 | 2.05*** | 1.67, 2.52 | 1.59*** | 1.36, 1.87 | 1.74** | 1.23, 2.46 |
| 2 | 1.22 | 0.51, 2.93 | 2.81** | 1.46, 5.42 | 1.03 | 0.39, 2.64 | |
| 3 | 0.74 | 0.27, 2.04 | 2.67** | 1.37, 5.23 | 1.25 | 0.48, 3.22 | |
| 4 | 0.84 | 0.35, 2.03 | 2.21* | 1.11, 4.37 | 1.04 | 0.41, 2.68 | |
| Truncal skinfolds | 1 | 1.73*** | 1.46, 2.07 | 1.49*** | 1.29, 1.72 | 1.57*** | 1.24, 1.98 |
| 2 | 1.21 | 0.94, 1.56 | 1.21 | 0.99, 1.49 | 1.34 | 0.96, 1.86 | |
| 3 | 1.02 | 0.77, 1.36 | 1.24 | 0.97, 1.57 | 1.28 | 0.89, 1.86 | |
| 4 | 1.11 | 0.86, 1.43 | 1.07 | 0.86, 1.33 | 1.27 | 0.89, 1.82 | |
| Leg skinfolds | 1 | 1.87*** | 1.38, 2.54 | 1.60** | 1.22, 2.11 | 1.13 | 0.54, 2.37 |
| 2 | 1.06 | 0.71, 1.59 | 1.03 | 0.73, 1.47 | 0.42 | 0.15, 1.22 | |
| 3 | 1.00 | 0.62, 1.60 | 1.08 | 0.72, 1.62 | 0.49 | 0.17. 1.41 | |
| 4 | 1.04 | 0.68, 1.58 | 0.87 | 0.61, 1.25 | 0.41 | 0.13, 1.19 | |
| In women | |||||||
| VAT | 1 | 2.35*** | 1.74, 3.19 | 1.80* | 1.01, 3.23 | 2.85*** | 1.84, 4.41 |
| 2 | 2.66* | 1.14, 6.20 | 1.24 | 0.59, 2.58 | 3.36** | 1.50, 7.53 | |
| 3 | 2.71* | 1.16, 6.34 | 1.07 | 0.49, 2.31 | 3.18** | 1.37, 7.39 | |
| 4 | 2.39 | 0.97, 5.89 | 0.96 | 0.45, 2.04 | 3.32* | 1.21, 9.11 | |
| SAT | 1 | 1.70*** | 1.37, 2.12 | 1.44 | 0.98, 2.12 | 1.29* | 1.05, 1.59 |
| 2 | 1.08 | 0.48, 2.46 | 0.82 | 0.26, 2.60 | 0.79 | 0.44, 1.43 | |
| 3 | 0.93 | 0.44, 1.96 | 0.94 | 0.29, 3.07 | 0.84 | 0.47, 1.51 | |
| 4 | 1.09 | 0.55, 2.18 | 0.90 | 0.28, 2.89 | 0.83 | 0.44, 1.56 | |
| Truncal skinfolds | 1 | 1.82*** | 1.38, 2.38 | 2.00** | 1.27, 3.13 | 1.70*** | 1.29, 2.23 |
| 2 | 1.43 | 0.93, 2.20 | 1.91* | 1.05, 3.48 | 1.65* | 1.07, 2.54 | |
| 3 | 1.23 | 0.74, 2.05 | 1.91* | 1.03, 3.56 | 1.42 | 0.86, 2.34 | |
| 4 | 1.37 | 0.89, 2.11 | 1.93* | 1.05, 3.55 | 1.44 | 0.89, 2.32 | |
| Leg skinfolds | 1 | 1.68** | 1.15, 2.44 | 1.59* | 1.04, 2.43 | 1.39 | 0.98, 1.97 |
| 2 | 1.19 | 0.80, 1.77 | 1.36 | 0.76, 2.43 | 1.07 | 0.59, 1.95 | |
| 3 | 1.07 | 0.69, 1.65 | 1.41 | 0.80, 2.45 | 1.19 | 0.64, 2.19 | |
| 4 | 1.23 | 0.84, 1.82 | 1.38 | 0.79, 2.43 | 1.20 | 0.64, 2.27 | |
SHR: subhazard ratio (competing risks models) showing the effect of a 1 SD increase in each adiposity measure on incident diabetes.
*
P < 0.05
**
P < 0.01
***
P < 0.001. Model 1: adjusted for age, model 2: adjusted for age + BMI, model 3: adjusted for age + BMI + smoking status + systolic blood pressure + HDL-cholesterol, model 4: adjusted for age + BMI + HOMA2-IR.
VAT: visceral adipose tissue; SAT: subcutaneous adipose tissue.