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. 2015 May 6;3(5):e12343. doi: 10.14814/phy2.12343

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Expression of FNDC5 is lower in muscle tissue from AMPK DMKO mice compared to wild-type mice but is unaltered after exhaustive treadmill exercise. (A) The maximum speed attained during a progressive treadmill running exercise capacity test in wild-type and AMPK DMKO mice. AMPK alpha pThr172 (B) and ACC2 pSer212 (C) phosphorylation levels and FNDC5 protein content (D) at rest (Rest) or immediately following exercise (Post Ex) in tibialis anterior muscle tissue (N = 3–5). Error bars represent standard error of the mean. ND, not detectable. *Significantly different from wild-type, P < 0.05. **Significantly different from wild-type Rest.