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. 2015 May 6;3(5):e12343. doi: 10.14814/phy2.12343

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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FNDC5 is not affected by acute or chronic AICAR treatment. Blood glucose (A) one hour after the administration of an acute I.P. injection of AICAR in wild-type mice (N = 6). ACC2 pSer212 (B) phosphorylation levels and Pgc1α and Fndc5 mRNA (C) and FNDC5 protein content (D) in tibialis anterior muscle of mice chronically treated with AICAR for 2 weeks (N = 5). Error bars represent standard error of the mean. *Significantly different from saline control. **Significantly different from basal and 1 h saline, P < 0.05.