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. 2015 May 27;3(5):e12344. doi: 10.14814/phy2.12344

Figure 9.

Figure 9

The AHP affects the temporal occurrence of the action potentials during the train. (A) Representative traces showing the latency, from the beginning of the current injection, of the first and the last spike of a train. (B) The effect of the spike train on AP latency increased as a function of the firing frequency in both group of age. Note that latency increase was significantly bigger in the P15 group for all tested MC firing frequencies except 80 Hz. (C) Depict the method used to calculate the prespike hyperpol, that is, the median amplitude of the membrane hyperpolarization (vertical arrow) in the 5 msec preceding the last spike of the train (horizontal arrow). (D and E) The increase in the AP latency correlates with the prespike hyperpol; the data show all prespike hyperpol for all frequencies in P15 D and P38 E groups. *Significantly difference between the two age groups. *P < 0.05; **P < 0.01; ***P < 0.001; Significantly difference between the first and the last spike of each frequency train. #P < 0.05; ##P < 0.01; ###P < 0.001.