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. 2015 May 6;3(5):e12381. doi: 10.14814/phy2.12381

Figure 1.

Figure 1

Effects of central insulin action on hepatic venous glucose concentration (HVGC) in nonanesthetized Wistar and SHR. (A) Basal levels of hepatic glucose (mg/dL) prior to injection of insulin and/or denatured insulin into the lateral ventricle (LV) of Wistar (n = 5) and SHR (n = 5). (B) Percentage (%) change in HVGC and area under the curve (C) after administration of insulin and/or denatured insulin (vehicle control) into the LV (arrow) of Wistar and SHR. (D) Schematic diagram of coronal section of the rat brain modified from the Atlas of Paxinos and Watson (2007) and a representative photomicrograph of a sagittal brain section in a higher magnification showing the injection track (arrow) of insulin and/or denatured insulin into the lateral ventricle (LV) of one representative animal. (n) Numbers of animals of each group; One-Way ANOVA; P < 0.01.