Figure 5.

Effects of sc infusion of Ang II at 200 ng/kg/min (left panels) and at 1000 ng/kg/min (right panels) on mean arterial pressure (MAP) during the day and night in wild-type (WT) controls (n = 6 and 5), Nedd4-2^−/− (n = 4 and 6), (n = 7 for high dose only), and /Nedd4-2^−/− (n = 4 and 4). Values represent the mean ± SEM of the changes from baseline (day −1 to 0). **P < 0.001; *P < 0.05 versus baseline. Between-group changes were compared for areas under the curve:

• BP Day: low dose – WT:122 ± 14, Nedd4-2^−/−: 109 ± 11 and Nedd4-2^−/−/: 172 ± 44.
• F-value 1.4, P = 0.29.
• High dose – WT:385 ± 71, Nedd4-2^−/−: 316 ± 53, : 266 ± 58 and
• Nedd4-2^−/−: 189 ± 23.
•  F-value 1.4, P = 0.20.
• BP Night: low dose – WT:128 ± 18, Nedd4-2^−/−: 121 ± 19 and Nedd4-2^−/−/: 147 ± 15.
•  F-value 0.5, P = 0.63.
• High dose – WT:407 ± 92, Nedd4-2^−/−: 227 ± 45, : 277 ± 57 and
• Nedd4-2^−/−: 161 ± 36.
• F-value 2.4, P = 0.10.