Table 3.

Distributed two-pore parameters for FITC-Ficoll

Model parameter	Control (N = 6)	Diabetic (N = 9)
Small-pore radius (rS), Å	37.1 ± 1.1	37.5 ± 0.5
Small-pore spread (sS)	1.15 ± 0.01	1.14 ± 0.00
Large-pore radius (rL), Å	94 ± 8	111 ± 9
Large-pore spread (sL), Å	1.34 ± 0.01	1.47 ± 0.02*
A0/Δx × 105, cm†	17 ± 5	8 ± 2
LpS, mL/min/mmHg†	0.38 ± 0.09	0.19 ± 0.05
αL × 105	5 ± 2	44 ± 13*
JvL/GFR × 105	32 ± 8	199 ± 45**
Volume recirculation (JvL,iso), μL/min†	0.3 ± 0.1	1.5 ± 0.7
A0,L/A0 × 106	8 ± 3	44 ± 21
GFR, mL/min†	1.20 ± 0.2	0.75 ± 0.2
Goodness of fit, χ2	0.25 ± 0.06	0.18 ± 0.02

A₀/Δx effective pore area over unit diffusion path length in centimeters; A_0,L/A₀ fractional large-pore area; L_pS hydraulic conductance (calculated from A₀/Δx); α_L fractional large-pore hydraulic conductance; J_vL/GFR fractional large-pore volume flux; χ² = “Goodness of fit”.

^*P < 0.05

^**P < 0.01.

^†Refers to both kidneys.