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. 2015 May 21;3(5):e12405. doi: 10.14814/phy2.12405

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© 2015 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Cyclic AMP assay of cilia (−) and cilia (+) collecting duct cells. (A). Baseline cAMP level was higher in cilia (−) cells compared to cilia (+) cells (P < 0.001). Both apical (AP) and apical + basolateral (AP+BL) Ang II (100 nmol/L) significantly increased cAMP in cilia (−) but not in cilia (+) cells (P < 0.05). This increase was inhibited but losartan (10 μmol/L). (B). Forskolin (10 μmol/L) was added to the apical solution which resulted in similar increase in intracellular cAMP in both cell lines (NS, n = 3).