Fig. 2.

TRIF is involved in the regulation of TNFα production after heat and LPS. Macrophages from WT, MYD88-deficient mice, or TRIF inactive mutant mice were stimulated with heat and (a) LPS or (b) CPG ODN1826 or (c) Poly(I:C) as described in Figure 1. ^# p < 0.05 vs WT 37 ºC control; *p < 0.05 vs respective 37 °C controls; ns:  not significant