Fig. 7.

Summary of pathways involved. Upon heat treatment and LPS stimulation, a ANXA1 promotes HSP70 expression transcriptionally and translationally. b This leads to increased MKP1 expression, c which in turn inhibits the activation of the MAP kinases JNK, ERK, and p38, d which leads to a reduction in TNFα production. e JNK can also inhibit HSP70 to control its expression. In the absence of ANXA1, f HSP70 expression is reduced, g which leads to lower MKP1 expression, h which in turn increases the activation of the MAP kinases JNK, ERK, and p38. i This results in an increase in TNFα production