Table 2.
Class I biomarker of liver fibrogenesis (cirrhosis)
| AUC | Sensitivity (%) | Specificity (%) | Method | Reference | |
|---|---|---|---|---|---|
| Mortalin autoantibody | 0.865 | 87.5 | 72 | ELISA | |
| Hyaluronic acid (hyaluronan) | 0.854 | 80 | 80 | ELISA | Saitou et al. 2005 |
| Connective tissue growth factor (CTGF/CCN2) | 0.829 | 78 | 87.5 | ELISA | Kovalenko et al. 2009 |
| YKL-40 | 0.795 | 80 | 71 | ELISA | Saitou et al. 2005 |
| N-terminal propeptide (PIIINP) | 0.79 | 77 | 66 | ELISA | Saitou et al. 2005 |
| Tissue inhibitor of metalloproteinases (TIMP-1) | 0.765 | 83.3 | 61.5 | ELISA | Pereira et al. 2004 |
| (Pro)matrix metalloproteinase (MMP-2) | 0.598 | 62.9 | 59.7 | ELISA | Pereira et al. 2004 |
| Type IV-collagen | 0.596 | 60 | 61 | ELISA | Saitou et al. 2005 |