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Plumbagin mediates Nrf-2 nuclear localization. Control and plumbagin showed nuclear localization of Nrf-2, whereas DEX treatment (p < 0.001) showed cytoplasmic localization of Nrf-2 when compared to control cells. Plumbagin + DEX treatment augmented Nrf-2 localization (p < 0.001) into nucleus compared to DEX treatment (Nrf-2 conjugated with FITC; Nucleus-DAPI). Scale bar = 100 μm
