Table 1.

Initiation strategy from Medical Advisory Board

•	Initiate treatment as early as possible when patient first experiences symptoms of migraine, including pain and/or aura symptoms.
•	Fill-out the headache diary immediately after treatment or at any time after the migraine attack subsides.
•	Record all symptoms, triggers and medications used during each attack in a diary
•	Increase the number of pulses delivered during an attack using the following systematic method as needed to improve pain and symptom relief.
To Begin:
•	Encourage the patient to deliver 2 sequential pulses as early as possible at the beginning of the migraine attack.
•	Continue with 2 pulses every 15 min for 1–2 h or until pain and symptoms resolve.
•	Encourage patients to withhold using rescue medication for the first hour or two if possible.
Evaluate after the first month (3–4 attacks) - if needed increase the number of pulses delivered
•	Encourage the patient to deliver 3 sequential pulses as early as possible at the beginning of the migraine attack.
•	Continue with 3 pulses every 15 min for 1–2 h or until pain and symptoms resolve.
Evaluate again after the second month (3–4 attacks) - if needed increase the number of pulses delivered
•	Encourage the patient to deliver 4 sequential pulses as early as possible at the beginning of the migraine attack.
•	Continue with 4 pulses every 15 min for 1–2 h or until pain and symptoms resolve.