Table 4.
Differences in signals between RV and LV in response to increased afterload
| Model | Mechanism | Difference with LV | Ref |
|---|---|---|---|
| Mouse PAB | Extracellular matrix proteins | ↑ expressed in RV | [38] |
| Proteases and inhibitors | ↑ expressed in RV | [38] | |
| Developmentally regulated proteins | only expressed in RV | [38] | |
| Rat PAB | PINK1 | ↓ in RVF, ↑ in LVF | [31, 114] |
| Mouse PAB vs TAC | miRNA 28,148a,93 | ↑ in RVF (in non-myocyt fraction) | [87] |
| Mouse PAB | Wnt signalling | ↑↑ in RVF > LVF | [29] |
| Rat MCT | Mef2c | ↑ compensated RV, ↓ RVF, no change LVF | [115] |
Overview of studies reporting differences in myocardial signaling between the RV and LV, in response to increased afterload
PAB pulmonary artery banding, TAC transverse aorta constriction, RVF RV failure, LVF LV failure