Table 2.
Resulting models and characteristics of each feature.
| Analysis | Feature | Coefficient | OR | Mean (SD) | |
|---|---|---|---|---|---|
| Controls | Cases | ||||
| HC-AD | Volume of left hippocampus | −2.8∗∗∗ | 273.11 | 0.52 (0.72) | −0.66 (0.82) |
| Globally normalized CMRgl from left angular gyrus | −2.02∗∗∗ | 56.59 | 0.5 (0.66) | −0.64 (1.15) | |
| Surface area of left superior frontal gyrus | 1.02∗∗ | 7.64 | −0.01 (0.82) | 0.11 (0.99) | |
|
| |||||
| HC-MCI | Ratio of CSF t-tau to Aβ42 | 1.63∗∗∗ | 25.97 | −0.54 (0.39) | 0.16 (0.95) |
| Volume of left hippocampus | −1.07∗∗∗ | 8.58 | 0.47 (0.59) | −0.17 (0.82) | |
| Standard deviation of the cortical thickness of the right temporal lobe | 0.72∗∗ | 4.23 | −0.49 (0.8) | 0.11 (1.01) | |
| Red blood cell count | 0.15 | 1.34 | −0.05 (0.71) | 0.16 (1.37) | |
| SPM VBM measure of the 4th and 5th vermal lobules | 0.53∗ | 2.91 | −0.03 (0.97) | 0.26 (0.97) | |
| Average cortical thickness of right medial orbitofrontal cortex | −1.03∗∗∗ | 7.8 | 0.54 (0.75) | −0.13 (0.86) | |
| Surface area of left temporal pole | 0.31 | 1.86 | −0.36 (0.78) | −0.24 (0.89) | |
| Whether the subject has suffered from endocrine-metabolic diseases | 0.36 | 2.07 | −0.24 (0.93) | −0.12 (0.98) | |
|
| |||||
| MCI-AD | Plasma concentration levels of complement component 3 | 1.18∗∗∗ | 10.49 | 0.01 (0.97) | 0.79 (1) |
| SPM VBM measure of the right middle temporal gyrus | −0.61∗∗ | 3.41 | 0.06 (1.03) | −0.47 (0.95) | |
| Sum of both alleles TOMM40 poly-T variable length | 0 | 1.01 | 0.04 (0.99) | 0.04 (0.92) | |
| Standard deviation of the cortical thickness of “left unknown” region | −0.72∗∗∗ | 4.23 | 0.02 (0.88) | −0.56 (0.85) | |
| Plasma concentration levels of monocyte chemotactic protein 4 | −0.97∗∗∗ | 7.01 | 0.16 (0.93) | −0.23 (0.83) | |
| Plasma concentration levels of apolipoprotein D | 0.73∗∗∗ | 4.3 | −0.15 (1.03) | 0.33 (0.9) | |
| Surface area of right lateral orbitofrontal cortex | 0.32 | 1.9 | −0.11 (0.93) | −0.11 (0.97) | |
Coefficients, odds ratios (OR), and p values were obtained using the calibration set. The “left unknown” region was defined also by the University of California at San Francisco FreeSurfer analysis group [29]. Control refers to HC subjects for the HC-AD and HC-MCI analyses and to MCI for the MCI-AD analysis. ∗∗∗, ∗∗, and ∗ symbols indicate a probability lower than 0.001, 0.01, and 0.05, respectively, for the logistic regression coefficient being worth zero.