Table 3.
Number of target genes that must be returned by each database, in order to retrieve (cover) a given percentage of validated interactions coming from miRTarBase and involving hsa-mir-17 and hsa-mir-20a, respectively.
| Covered % | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Database | No. Interactions | 10% | 20% | 30% | 40% | 50% | 60% | 70% | AUPRC |
| Diana-micro T | 4106 | 359 | 1010 | 1999 | - | - | - | - | 0.0252 |
| microCosm | 1197 | - | - | - | - | - | - | - | 0.0010 |
| picTar 4-way | 0 | - | - | - | - | - | - | - | 0.0000 |
| picTar 5-way | 0 | - | - | - | - | - | - | - | 0.0000 |
| PITA All Targets | 8027 | 431 | 1373 | 2860 | 4710 | 6776 | - | - | 0.0233 |
| PITA Top Targets | 859 | 349 | - | - | - | - | - | - | 0.0157 |
| TargetScan C | 991 | 538 | 890 | - | - | - | - | - | 0.0135 |
| TargetScan NC | 2954 | 1250 | 2507 | - | - | - | - | - | 0.0057 |
| Miranda | 2336 | 920 | 1687 | - | - | - | - | - | 0.0087 |
| RNA22 3' UTR | 0 | - | - | - | - | - | - | - | 0.0000 |
| mirDIP | 20470 | 669 | 1813 | 3455 | 5653 | 9821 | - | - | 0.0173 |
| TarMir | 6759 | 564 | 1186 | 2562 | 4175 | 6464 | - | - | 0.0216 |
| ComiRNet | 9218 | 32 | 623 | 1647 | 4500 | 7854 | - | - | 0.1664 |
| Covered % | |||||||||
| Database | No. Interactions | 10% | 20% | 30% | 40% | 50% | 60% | 70% | AUPRC |
| Diana-micro T | 3857 | 326 | 798 | 1608 | 3789 | - | - | - | 0.0170 |
| microCosm | 1029 | - | - | - | - | - | - | - | 0.0008 |
| picTar 4-way | 610 | 278 | - | - | - | - | - | - | 0.0122 |
| picTar 5-way | 268 | - | - | - | - | - | - | - | 0.0040 |
| PITA All Targets | 8027 | 940 | 2095 | 3602 | 5035 | 6600 | - | - | 0.0090 |
| PITA Top Targets | 859 | 390 | - | - | - | - | - | - | 0.0087 |
| TargetScan C | 990 | 466 | 869 | - | - | - | - | - | 0.0083 |
| TargetScan NC | 2954 | 957 | 2389 | - | - | - | - | - | 0.0039 |
| Miranda | 2499 | 536 | 1410 | - | - | - | - | - | 0.0085 |
| RNA22 3' UTR | 1640 | 1153 | - | - | - | - | - | - | 0.0022 |
| mirDIP | 23873 | 493 | 1367 | 2861 | 5658 | 8755 | 12834 | - | 0.0130 |
| TarMir | 5963 | 427 | 1165 | 2108 | 3831 | - | - | - | 0.0142 |
| ComiRNet | 9879 | 18 | 599 | 1540 | 3983 | 6900 | 9524 | - | 0.1624 |
No. Interactions is the total number of interactions in a given database which involve the specified miRNA. The symbol "-" indicates that the database does not contain the specified percentage of interactions of miRTarBase. AUPRC is the area under the precision-recall curves (i.e. the area under the lines in Figures 5 and 6).