Flowchart describing 5DCT image generation. Several scans were acquired with breathing surrogate measurements. One scan was chosen as the reference image and deformably registered to the others. A motion model was used to generate a deformation vector field, R, which gave each voxel’s displacement from the reference breathing phase (v0,f0) to a user selected phase (v1,f1) as a function of breathing amplitude v, rate f, and position x0,y0,z0. R was then used to deform the reference, creating a new image at breathing phase (v1,f1).