TABLE IV.
Effects of adjusting SUV for uptake time (n = 35 lesions).
| Prone, median (range) | Supine, median (range) | P vs S median, P valuea | Prone errorb, median (range) | Supine errorb, median (range) | P vs S error,P valuea | |
|---|---|---|---|---|---|---|
| SUVpeak | ||||||
| Original value | 7.60 (1.60–20.5) | 8.99 (1.73–22.7) | 1.24 × 10−06 | n/a | n/a | n/a |
| Corrected valuec | ||||||
| ti = 45 min | 6.39 (1.77–16.8) | 7.11 (1.95–16.9) | 1.78 × 10−05 | 11.3 (0.97–22.7) | 18.2 (0.42–32.1) | 1.40 × 10−06 |
| ti = 60 min | 7.16 (1.60–19.6) | 8.03 (1.82–19.8) | 1.78 × 10−05 | 1.14 (0.00–12.4) | 8.26 (0.00–20.8) | 2.16 × 10−06 |
| ti = 75 min | 7.92 (1.43–22.5) | 8.94 (1.68–22.7) | 1.78 × 10−05 | 8.49 (0.97–18.5) | 2.16 (0.02–10.8) | 6.60 × 10−05 |
| ti = 90 min | 8.69 (1.27–25.4) | 9.86 (1.55–25.6) | 1.78 × 10−05 | 19.3 (1.94–32.1) | 10.3 (0.34–20.8) | 1.29 × 10−06 |
| SUVmax | ||||||
| Original value | 9.28 (1.90–21.7) | 11.4 (2.09–26.1) | 2.09 × 10−06 | n/a | n/a | n/a |
| Corrected valuec | ||||||
| ti = 45 min | 7.79 (2.11–17.3) | 8.73 (2.33–18.1) | 1.48 × 10−04 | 13.5 (1.94–24.5) | 21.1 (1.52–34.9) | 1.18 × 10−06 |
| ti = 60 min | 8.90 (1.90–20.7) | 10.1 (2.18–21.6) | 1.48 × 10−04 | 1.25 (0.00–13.4) | 9.70 (0.79–22.6) | 9.91 × 10−07 |
| ti = 75 min | 10.0 (1.69–24.0) | 11.4 (2.03–25.1) | 1.48 × 10−04 | 10.5 (1.31–21.3) | 2.45 (0.01–12.0) | 6.13 × 10−05 |
| ti = 90 min | 11.1 (1.49–27.3) | 12.7 (1.88–28.6) | 1.48 × 10−04 | 22.1 (3.24–36.9) | 12.4 (0.67–23.1) | 1.08 × 10−06 |
Note: FDG = fluorodeoxyglucose; SUV = standardized uptake value.
a
Bonferroni-corrected Wilcoxon signed rank test.
b
Pairwise correction percent error = |original value − corrected value|/original value.
c
Original prone and supine lesion SUVpeak or SUVmax were corrected for intersubject differences in FDG uptake time according to the method of Beaulieu et al. (Ref. 10) using index times (ti) encompassing the range of uptake times for the clinical data.