Figure 4. LTP of C-fiber-evoked responses in single WDR dorsal horn neurons in % of baseline (mean±SEM). (A) C-fiber evoked-responses between experimental groups. HFS was applied to sciatic nerve at time zero. Post-HFS responses were recorded every 4 min up to 2 h. The effect of intrathecal injection of 7-NI (8.15 µg/5 µl) on C-fiber-evoked responses in neuropathic rats is demonstrated. (B) Statistical comparison of the % of potentiation of C-fiber-evoked responses at time 0-2 h after HFS. The values are based on the average of three consecutive responses. *p<0.05, indicates a significant difference with sham animals. #p<0.05, indicates a significant difference with neuropathic rats.
