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. 2015 Jun 12;6:166. doi: 10.3389/fphys.2015.00166

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Copyright © 2015 Thornell and Bevensee.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulators of AE1. The general position(s) of known or potential target site(s) within AE1 for each regulator is/are shown. Stimulatory effects are depicted by green arrows and inhibitory effects are depicted by red lines. These effects involve changes in transport function and/or plasma membrane expression, and may be variant dependent. The target site of protein 4.2 is unknown within the cytosolic N terminus of AE1. The AE1 topology is based on that presented in Cordat and Reithmeier (2014). AE1, anion exchanger 1; AP-1, adapter protein-1; CA, carbonic anhydrase; GAPDH, glyceraldehyde-3-phosphate dehydrogenase; GPA, glycophorin A.