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. 2015 Jun 11;5:10081. doi: 10.1038/srep10081

Figure 4. CSC property of FoxO1-negative PDACs were supported by tumor sphere formation and adoptive transfer.

Figure 4

(a,b) We put FoxO1-negative and FoxO1-positive cells into the tumor sphere media (TSM). We found that only FoxO1-negative cells significantly formed sphere-like structures, while FoxO1-negative cells did not, shown by representative images (a), and by quantification (b). (c,d) Serial adoptive transfer of FoxO1-negative cells, but not serial adoptive transfer of FoxO1-negative cells, developed tumors in receipt NOD/SCID mice, shown by quantification (c) and by representative bioluminescent images (d). *p < 0.05. n = 5. Statistics: one-way ANOVA with a Bonferoni correction, followed by Fisher’s exact test.