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Potential of mean force with alternative backward protocol Potential of mean force (PMF) as a function of the distance between the centers of mass of the L2 and L3 loops. Results for Apo form are shown in red (Bwd (k = 20)) as obtained from the control umbrella sampling simulations discussed in the Appendix, and aligned with the other two Apo profiles described in the Methods section (Fwd in orange, Bwd (k = 40) in black) for comparison.
