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. 2015 Apr 18;5:10. doi: 10.1186/s13395-015-0035-9

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© Paolini et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Increased incidence of unstructured and contracture cores in 14- to 27-month-old CASQ1-null mice. While the percentage of fibers in WT mice exhibiting structural cores remained low across all ages (maximum of 8% at 27 months of age), muscle fibers from CASQ1-null mice exhibited a significantly increased frequency (*P < 0.05) of structural cores from 4 months of age (approximately 2%) to 14 months (23%), remaining approximately unchanged thereafter (see also Additional file 2: Table S1 for additional detail). CASQ1, skeletal isoform of calsequestrin; WT, wild type.