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. 2015 Jun 11;5:9750. doi: 10.1038/srep09750

Figure 6. 17,18-EpETE prevents the development of allergic diarrhea by impairing MC degranulation.

Figure 6

(A) Mice were injected i.p. without (mock) or with 100 ng 17,18-EpETE, 14,15-EpETE, or 17,18-diHETE 30 min before systemic priming and oral challenge with OVA, after which the incidence of allergic diarrhea was measured (n = 16 per each group). (B) Mice were injected i.p. without (mock) or with 100 ng 17,18-EpETE at 24 and 1 hr before oral inoculation of 25 μg cholera toxin. Fifteen hours after oral administration of cholera toxin, water volume in the intestinal lumen was measured. The data represent the mean ± 1 SD (n = 4). (C, D) One day after the eighth oral challenge with OVA, serum was collected for the measurement of OVA-specific IgE (C) and mMCP-1 (D) levels. Graphs show data from individual mice from 2 individual experiments, and bars indicate median values.