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. 2015 Jun 12;6:301. doi: 10.3389/fimmu.2015.00301

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Copyright © 2015 Nagasawa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CXCL12-abundant reticular (CAR) cells. In adult bone marrow, the transcription factor Foxc1 induces development of CAR cells and maintains bone marrow niches for HSPCs, up-regulating the expression of CXCL12, which is essential for the maintenance of HSCs, common lymphoid progenitors (CLPs), B cells, pDCs, and NK cells, in CAR cells.