Skip to main content
. 2015 Jun 12;5:10867. doi: 10.1038/srep10867

Figure 1. Cav-1 expression is up-regulated in pancreatic cancer and is associated with increased tumor grade and worse clinical outcomes.

Figure 1

A. Western blot images showing expression of Cav-1 in normal and PC cells with GAPDH as a loading control. B. Left -Immunohistochemistry (IHC) staining of normal human pancreatic tissue (n = 4), xenograft tumor tissues derived from MIAPaCa-2 cells (n = 2), human patient-derived xenografts (n = 3), and tumors from KPC transgenic mice (n = 3), showing increased Cav-1 staining in pancreatic cancer compared to normal pancreatic tissue (inset at greater magnification). Right - Representative Cav-1 IHC staining of cores from a tissue microarray showing weak, intermediate, and strong intensity, with intensity scores of 1, 2, and 3 respectively. C. Mean Cav-1 IHC Allred score based on degree of tumor differentiation (well, moderate, poor). D. Low Cav-1 expression (Allred score 0-4) is significantly associated with improved RFS and DFS, with a trend towards improved OS, compared to high Cav-1 expression (Allred score 5-8).