Table II.
Functional enrichment analysis of the differentially expressed genes in the subnetworks.
| Subnetwork | Term | P-value | Gene |
|---|---|---|---|
| 1 | GO:0007049: cell cycle | 1.11E-23 | FOXM1, ANLN, CEP55, AURKB, CCNE2, KIF2C, SPC25, CDC45, NCAPH, MCM7, NCAPG2, BUB1, CCNA2, CDC6, MKI67, PDS5A, DSN1, GMNN, DLGAP5, SKP2, ESPL1, RACGAP1, RAD54L, NCAPD3, MCM6, PLK2, SPAG5, FANCD2, DSCC1 |
| GO:0000279: M phase | 2.85E-19 | CDC6, MKI67, PDS5A, DSN1, DLGAP5, ANLN, ESPL1, AURKB, CEP55, RAD54L, NCAPD3, SPC25, KIF2C, NCAPH, NCAPG2, FANCD2, SPAG5, BUB1, CCNA2, DSCC1 | |
| GO:0022403: cell cycle phase | 8.57E-19 | CDC6, MKI67, PDS5A, DSN1, DLGAP5, SKP2, ANLN, ESPL1, AURKB, CEP55, RAD54L, NCAPD3, SPC25, KIF2C, NCAPH, NCAPG2, FANCD2, SPAG5, BUB1, CCNA2, DSCC1 | |
| GO:0007067: mitosis | 8.67E-18 | CDC6, PDS5A, DSN1, DLGAP5, ANLN, ESPL1, AURKB, CEP55, NCAPD3, SPC25, KIF2C, NCAPH, NCAPG2, SPAG5, BUB1, CCNA2, DSCC1 | |
| GO:0000280: nuclear division | 8.67E-18 | CDC6, PDS5A, DSN1, DLGAP5, ANLN, ESPL1, AURKB, CEP55, NCAPD3, SPC25, KIF2C, NCAPH, NCAPG2, SPAG5, BUB1, CCNA2, DSCC1 | |
| hsa04110: ell cycle | 9.91E-11 | CCNE2, CDC6, CDC45, MCM7, SKP2, BUB1, ESPL1, CCNA2, MCM5, MCM6 | |
| hsa03030: DNA replication | 6.04E-06 | MCM7, POLE2, RFC2, MCM5, MCM6 | |
| hsa00240: yrimidine metabolism | 2.86E-04 | POLE2, RRM2, RRM1, TK1, DUT | |
| 2 | GO:0006793: phosphorus metabolic process | 0.03 | MTM1, MTMR1, ATP6AP1, PGK1, MST4 |
| GO:0006796: phosphate metabolic process | 0.03 | MTM1, MTMR1, ATP6AP1, PGK1, MST4 | |
| 4 | GO:0051297: centrosome organization | 0.039 | CETN2, HAUS7 |
| GO:0031023: microtubule organizing center organization | 0.043 | CETN2, HAUS7 |