Table II.
Enriched GO biological processed of DEGs.
| A, Enriched GO biological processes of downregulated DEGs
| |||
|---|---|---|---|
| GO term and function | P-value | DEGs | Benjamini |
| 0006695: Cholesterol biosynthetic process | 2.48×10−13 | CYP51, EBP, HMGCR, DHCR7, HMGCS1, MVK, IDI1, PMVK, HSD17B7, NSDHL, FDFT1 | 3.33×10−10 |
| 0016126: Sterol biosynthetic process | 2.16×10−12 | CYP51, EBP, HMGCR, DHCR7, HMGCS1, MVK, IDI1, PMVK, HSD17B7, NSDHL, FDFT1 | 1.45×10−9 |
| 0008203: Cholesterol metabolic process | 5.61×10−12 | CYP51, EBP, HMGCR, HMGCS1, PMVK, FDFT1, SREBF2, SQLE, DHCR7, MVK, IDI1, HSD17B7, NSDHL, VLDLR | 2.52×10−9 |
| 0016125: Sterol metabolic process | 1.63×10−11 | CYP51, EBP, HMGCR, HMGCS1, PMVK, FDFT1, SREBF2, SQLE, DHCR7, MVK, IDI1, HSD17B7, NSDHL, VLDLR | 5.50×10−9 |
| 0008610: Lipid biosynthetic process | 6.70×10−11 | SCD1, CYP51, EBP, HMGCR, FA2H, NDUFAB1, HMGCS1, ACLY, ACSS2, PMVK, FDFT1, SREBF2, FAR1, AGPS, DHCR7, RGD1560015, MVK, PCYT2, AGPAT4, IDI1, HSD17B7, NSDHL | 1.80×10−8 |
| 0006694: Steroid biosynthetic process | 2.24×10−9 | CYP51, EBP, HMGCR, RGD1560015, DHCR7, HMGCS1, MVK, IDI1, PMVK, HSD17B7, NSDHL, FDFT1 | 5.03×10−7 |
| 0008202: Steroid metabolic process | 3.08×10−8 5.91×10−6 |
CYP51, EBP, HMGCR, HMGCS1, PMVK, FDFT1, SREBF2, SQLE, DHCR7, RGD1560015, MVK, IDI1, HSD17B7, NSDHL, VLDLR | |
| B, Enriched GO biological processes of upregulated DEGs
| |||
|---|---|---|---|
| GO term and function | P-value | DEGs | Benjamini |
| 0010033: Response to organic substance | 1.24×10−7 | RT1-M3-1, GJA1, CDH1, C1S, TIMP2, MDK, CXCL12, TIMP3, SDC2, TGFB2, B2M, GSTM2, SORBS1, APOE, SULT1A1, LCAT, GPX3, CD4, BOC, NR1H3, SREBF1, TXNIP, PLAT, CFB, SLC22A8, IGF2, NR4A3, STAT1, PRKCD, CYP7B1, CDKN1B, ID2, PTGDS, BTG1, ALDH2, NFE2L2, ID3, IGFBP2, MGST1 | 2.38×10−4 |
| 0042493: Response to drug | 2.84×10−5 | TXNIP, SREBF1, ATP1A1, CDH1, IGF2, TIMP2, STAT1, MDK, PRKCD, MMP12, TGFB2, B2M, CYP7B1, CDKN1B, GPX3, SLC22A5, IGFBP2, MGST1 | 2.68×10−2 |
| 0009611: Response to wounding | 7.28×10−5 | CFB, CLU, EPHX2, GJA1, SERPING1, C1S, MUSTN1, TIMP3, MDK, SDC2, GAS6, TGFB2, VCAM1, LAMB2, GRIN2C, APOE, VNN1, ID3, ENTPD2, RAB27A | 4.54×10−2 |
| 0042127: Regulation of cell proliferation | 9.35×10−5 | IFITM3, CLU, PAX6, GJA1, SOX4, PRRX2, IL34, TIMP2, DDR2, CXCL12, TGFB2, VCAM1, EDNRB, APOE, HEY2, TXNIP, CRIP2, STAT1, MMP12, CYP7B1, CDKN1B, ID2, DBP, BTG1, ID3, PMP22 | 4.38×10−2 |
| 0009725: Response to hormone stimulus | 1.01×10−4 | PLAT, TXNIP, SREBF1, GJA1, IGF2, NR4A3, STAT1, PRKCD, MDK, TIMP3, CXCL12, TGFB2, CDKN1B, PTGDS, SORBS1, BTG1, SULT1A1, LCAT, GPX3, ALDH2, IGFBP2, NR1H3 | 3.79×10−2 |
| 0009719: Response to endogenous stimulus | 1.88×10−4 | PLAT, SREBF1, TXNIP, GJA1, IGF2, NR4A3, STAT1, PRKCD, MDK, TIMP3, CXCL12, TGFB2, CDKN1B, PTGDS, SORBS1, BTG1, SULT1A1, LCAT, GPX3, ALDH2, IGFBP2, MGST1, NR1H3 | 5.82×10−2 |
The Benjamini value is a parameter generated during adjustment of the P-value for multiple comparisons. DEG, differentially expressed gene; GO, gene ontology.