Table 3. Pharmacokinetic parameters of DIC in rabbit aqueous humor after instillation of 50 μL of either 0.1% (mass fraction) DIC commercial eye drops or 0.1% (mass fraction) DIC/MPEG-PCL-CS nanosuspension.

Pharmacokinetic parameters	DIC/MPEG-PCL-CS nanosuspension	DIC commercial eye drops
AUC0–24 (μg/mL h)	3.06 ± 0.57*	1.33 ± 0.23
Cmax (μg/mL)	0.78 ± 0.11*	0.37 ± 0.03
Tmax (h)	2	1.5

^*Data were analyzed for statistical significance by one-way analysis of variance. P < 0.05 was considered as significant. P < 0.01 versus commercial DIC eye drops.