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. 2014 Sep 9;13:1055–1074.

Figure 5. Effect of 3-hydroxyflavones on serum insulin, HOMA-IR and insulin tolerance in FD-fed rats.

Figure 5

A: Fasting serum insulin (µIU/ml); B: HOMA-IR: Defined as homeostatic model assessment of insulin resistance and calculated by the formula HOMA-IR = [fasting plasma glucose (mg/dl) x fasting plasma insulin (µIU/ml)]/405; C: K-ITT: Defined as first-order rate constant for the disappearance rate of glucose from plasma was estimated from the slope of the regression line of the log plot of blood glucose against time; G1: Normal control; G2: FD-fed diabetic control; G3: Diabetic + pioglitazone (10 mg/kg/day, p.o.); G4: Diabetic + Quercetin (10 mg/kg/day, p.o.); G5: Diabetic + JY-1; G6: Diabetic + JY-2; G7: Diabetic + JY-3; G8: Diabetic + JY-4; (test compounds at optimized dose 80 mg/kg/day, p.o.); a: p < 0.05 treatment groups are compared to normal control (G1); b: p < 0.05 treatment groups are compared to FD-fed diabetic control group (G2).