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. 2015 Jun 12;5:11432. doi: 10.1038/srep11432

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Copyright © 2015, Macmillan Publishers Limited

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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(a) A functional network of BRCA1 target genes based on HumanNet links is shown. (b) The physical interaction network of TFs that regulate BRCA1 based on literature-curated protein-protein interactions derived from major databases is shown. (c) A network of TFs that are predicted to cooperate with BRCA1 based on literature-curated protein-protein interactions derived from major databases is shown. (d) Disease Ontology terms prioritized for BRCA1 are listed. The top three associated diseases, breast carcinoma, prostate carcinoma, and malignant neoplasm of pancreas, are all validated by the literature.