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. 2015 Jun 12;5:10009. doi: 10.1038/srep10009

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Copyright © 2015, Macmillan Publishers Limited

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K_V7.1 or K_V7.1–Y552S were expressed with KCNE1 in a 1:1 molar ratio in X. laevis oocytes. a: Representative recordings. The voltage protocol is shown as inset. b: IV relationship for K_V7.1 measured from points indicated with the filled square in A (at 40 mV; 2.9 ± 0.2 μA, n = 36), K_V7.1–Y522S (at 40 mV; 0.5 ± 0.1 μA, n = 12), and hetero (at 40 mV; 1.8 ± 0.2 μA, n = 27). c: Voltage-dependent activation as measured peak tail current indicated by the open square in A. For K_V7.1, the half-maximal activation voltage (V_1/2) was 31.1 ± 0.7 mV; for K_V7.1–Y522S: V_1/2 = 38.4 ± 4.4 mV, and hetero: V_1/2 = 28.6 ± 1.1 mV. d: Deactivation time constants were obtained by fitting a mono-exponential function to the tail-currents. The protocol is shown as inset. e: Activation time, determined as time-to-half maximal current at + 20, 30 or 40 mV. *P < 0.05, **P < 0.01, ***P < 0.001.