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. 2015 Apr 15;12(2):1639–1644. doi: 10.3892/mmr.2015.3613

Figure 2.

Figure 2

Effect of betaine on HIF-1α expression in the retina. Upper: Western blot analysis of HIF-1α expression. Actin was used as the internal control. Lower: Immunohistochemical analysis of HIF-1α expression. Scale bar, 25 mm. Values are presented as the mean ± standard error of the mean. (A) Control group, (B) STZ-induced diabetes group, (C) STZ-induced diabetes and 250 mg/kg of betaine-treated group and (D) STZ-induced diabetes and 500 mg/kg betaine-treated group. *P<0.05 compared with the control group. #P<0.05 compared with the STZ-induced diabetes group. STZ, streptozotocin; HIF-1α, hypoxia inducible factor-1α.