Table II.

Deregulated genes in GO analysis.

GO ID	Term	P-value	Gene
GO:0050793	Regulation of developmental process	9.6E-09	SOX2, VEGFC, CD24, TP53, DLC1, CDC42EP2, PDPN, CDC42EP1, AKAP2, FGD4, GAS2, ITGB2, PALM, FBLIM1, RHOU, ARAP3, GAS7, FGD3, TAOK2, AGRN, E4F1, CST3, PLA2G10, PPARG, ABCG1, HDAC5, NKX2-5, CENPF, SPINK5, KLK3, FOXO4, PLG, THBS1, LIF, GLI2, PBX1, ADRB2, ENPP1, BMP2K, ANKH, BMPR1B, ACVR2A, ECM1, AHSG, SOX9, NTN1, ALOX15B, NEFL, KLK8, PTHLH, IL7R, SPN, DEAF1, IL1B, TNFRSF11B, CD83, INPP5D, CD27, TCFL5, KLK6, FST, IAPP, WNT4, MAPK1, CLU, SOCS3, TAZ, FNDC3B, AQP3, NOTCH1, MUM1, IL4R, RARA, MAFB, ETS1, L3MBTL, TESC, ACIN1, MBNL3, IGFBP3, ATN1, FOXA2, LMX1A, MIB1, ISL2, NRP1, IL6, HGF, CCL5, NAB2, RNH1, F3, DDAH1, IL1A, RHOB, ANGPTL4, LUC7L, SOX15, INSR, LAMA3, LAMA3, LAMA5, BAX, BCL2L11, STAT6, TNFSF13, CD40, ULK1, FEZ1, CHRNB2, SEMA3A, NRP1, EFNA1, MAG, ARHGEF1, AMIGO1, DBN1, TGFBR2, NRG1, MORF4L2, CXADR, RBP4, HGF, MESP1
GO:0023034	Intracellular signaling pathway	0.00000012	CD24, SIGIRR, AGPAT2, TLR6, HSPD1, CD40, APC2, FZD10, CSNK1G2, AES, DVL1, CELSR2, HBP1, INVS, DACT1, PIAS4, KLHL12, FBXW4, TCF7, WNT4, WNT6, WNT7B, WNT11, WNT10A, ZFYVE28, TP53, ERN1, EPHB3, ERBB4, MUSK, NRTN, ROR1, MAL, ADRB2, PILRB, PDGFC, GRB7, AREG, CAMLG, PSEN2, ARRB2, CCL2, TGFBR2, GDF15, EID2, FKBP1A, PTPRE, TRIO, GRID2, F3, CFD, NRG1, MESP1, MIB1, NCSTN, NOTCH1, FOXF1, HIPK2, IFT52, VAV3, ITGA2, ITGAE, ITGB2, LAMA5, CEACAM1, CD47, TRPV4, BAIAP2, AKT2, INSR, FOXO4, PHIP, PIK3R3, IRS2, FGF12, FGFR3, PTCH1, F3, SNCA, SMAD6, CEBPA, KLF6, CSF2RB, EDN2, IL1A, IL1B, KRAS, IRAK4, DUOX1, STAT4, STAT6, GLI2, PPM1A, SOX4, ZEB2, DKK3, TAX1BP3, LRP1, WWOX, CHD8, SOX17, MED12, FST, BMPR1B, HOXA13, PCSK6, RGMA, ACVR2A, CDKN1C, GIPC1, THBS1, CHST11, VCP, MAPK1, TRIB1, PYDC1, CLN3, AGRN, PICK1, IGFBP2, AFAP1L2, SOX2, GAS1, AHSG, GRB14, IRS1, ENPP1, SOCS3, MYO1C, ZFAND5, SGPL1, VEGFC, NRP1, SORT1, HGF, EFNA1, EPHA1, CTF1, LIF, CACNB3, ELF1, ULK1, PROP1, RARG, HSP90AB1, IL6, HGF
GO:0016265	Death	0.00000074	IL6, HGF, BCL2L11, BAX, CLU, BBC3, TP53, CADM1, CD24, SEMA3A, LRP1, VAV3, IL24, AKAP13, FGD4, TRIM69, DNASE2, ECE1, ERN1, EYA2, UNC5B, PHLDA1, ACIN1, ARHGEF9, MCF2L, NCSTN, DAPK2, NGEF, GAS2, TIAM2, TNFRSF21, PDCD4, CECR2, HIPK2, UBQLN1, HRAS, IAPP, IL1A, ITGB2, USP17, NAIP, TNFRSF11B, PDCD2, WWOX, PLG, CYCS, PPP2R2B, DRAM1, LRDD, EAF2, PREX1, PTPN6, PTPRH, ELMO2, PERP, AKTIP, SGK1, LGALS7B, HGF, THBS1, TRIO, YWHAE, CXCR4, FASTKD1, ELMO3, HINT2, GRIP1, SGPL1, FGD3, RABEP1, STK17B, STK17A, TAOK2, CD27, NTN1, BRE, ARHGEF11, EEF1A2, F3, ATF1, HGF, HMGB1, HSPA1A, AMIGO2, IKBKB, IL1B, SERPINB2, CCL2, SNCA, ARC, SOCS3, DLC1, UNC13B, EIF5A, NLRP1, ALOX15B, PCSK9, MAL, NRP1, PPARG, MAPK1, BIK, BOK, TGM2, CASP1, TNFSF10, F2R, PSAP, HSPD1, VCP, RHOB, KLK8, CLN3, TTBK2, CTSD, DPP6, ATN1, L1CAM, OLR1, PSEN2, CABC1, SMPD1, SPG7, FA2H, FIG4, GAS1, C5, SORT1, SPN, CD5, MAGED1, ABL1, PRODH, DLC1, CASP9, NKX2-5, CST3, PSME3, CST6, CTSB, CARD8, CARD10, MNT, SOX9, TRAF1, ACTN4, BMF, SHARPIN, HDAC6, ADRB2, HOXA13, IGFBP3, INPP5D, MMP9, NOTCH1, IP6K2, ADAMTSL4, MAP2K6, PTGS2, KIAA1967, RARG, RXRA, SOX4, STK4, FOSL1, DHRS2, SMAD6, CHST11, ANGPTL4, PIM1, FAIM, PROP1, CHD8, PSMC5, SOX2, UNQ1887, GRID2, KRAS, NEFL, PIGT, AFG3L2
GO:0006915	Apoptosis	0.000001	IL6, HGF, BCL2L11, BAX, CLU, BBC3, TP53, CADM1, CD24, CECR2, CYCS, EEF1A2, F3, ATF1, HGF, HMGB1, HSPA1A, AMIGO2, IKBKB, IL1A, IL1B, NAIP, SERPINB2, CCL2, SNCA, THBS1, ARC, SOCS3, CD27, DLC1, UNC13B, EIF5A, ERN1, PHLDA1, NLRP1, DAPK2, ALOX15B, PCSK9, MAL, NRP1, WWOX, PLG, PPARG, MAPK1, BIK, PERP, BOK, TGM2, CASP1, TNFSF10, STK17B, STK17A, F2R, PSAP, HSPD1, VCP, RHOB, VAV3, AKAP13, FGD4, ARHGEF9, MCF2L, NCSTN, NGEF, TIAM2, PSEN2, PREX1, SORT1, HGF, SPN, TRIO, YWHAE, FGD3, CD5, MAGED1, ARHGEF11, HIPK2, GRIP1, ABL1, PRODH, DLC1, CASP9, NKX2-5, PSME3, CST6, CTSB, CARD8, GAS1, CARD10, MNT, SOX9, TRAF1, ACTN4, BMF, SHARPIN, ACIN1, HDAC6, ADRB2, HOXA13, IGFBP3, INPP5D, MMP9, NOTCH1, IP6K2, ADAMTSL4, MAP2K6, PTGS2, KIAA1967, RARG, RXRA, SMPD1, SOX4, STK4, FOSL1, DHRS2, SMAD6, CHST11, ANGPTL4, PIM1, FAIM, PROP1, CHD8, SOX2, UNQ1887, GRID2, CLN3, HRAS, KRAS, NEFL, PIGT, SEMA3A, LRP1, IL24, TRIM69, DNASE2, ECE1, EYA2, UNC5B, GAS2, TNFRSF21, PDCD4, UBQLN1, IAPP, ITGB2, USP17, TNFRSF11B, PDCD2, PPP2R2B, DRAM1, LRDD, EAF2, PTPN6, PTPRH, ELMO2, AKTIP, SGK1, LGALS7B, CXCR4, FASTKD1, ELMO3, HINT2, SGPL1, RABEP1, TAOK2, NTN1, BRE
GO:0010646	Regulation of cell communication	0.000002	EFNA1, HGF, IL1B, INSR, MAP2K6, THBS1, C5, CXCR4, DUSP2, DUSP6, PCSK9, ECE1, SNCA, CD24, SIGIRR, AGPAT2, ARRB2, ADRB2, ZFYVE28, PSEN2, TLR6, CARD10, FGD4, ABP1, PKN1, PTCH1, PSAP, HDAC6, KIF26A, IGFBP3, INPP5D, RGS9BP, F3, SMAD6, CLN3, FST, EDN2, DVL1, PPM1A, SOX4, ZEB2, DKK3, TAX1BP3, LRP1, WWOX, CHD8, SOX17, MED12, HOXA13, PCSK6, RGMA, ACVR2A, CDKN1C, GIPC1, HIPK2, EID2, CHST11, KLK8, TRIB1, PTGS2, SLC7A1, IQSEC2, IQSEC1, GK, PFKFB2, RBP4, TACR1, CHRNB2, HRAS, KRAS, ERBB4, ADAP2, ARAP3, TBC1D7, TBC1D8B, GRTP1, TBCK, SGSM2, RABGAP1L, RAP1GAP, PAFAH1B1, FKBP1A, NCOA3, FARP1, VAV3, AKAP13, PLEKHG4B, ARHGEF9, MCF2L, NGEF, TIAM2, ITSN2, ARHGEF10L, PREX1, HGF, TRIO, FGD3, ARHGEF1, ARHGEF10, ARHGEF11, DLC1, WNT4, IL6, HGF, LIF, ARHGAP27, IKBKB, TRIM38, ECM1, F2R, ZDHHC13, PPP5C, TGM2, TRAF1, CASP1, TNFSF10, VAPA, CD40, CARD8, SOX2, PDCD4, IGFBP2, AFAP1L2, KLK5, KLK6, GAS1, AKT2, TAOK3, EDA2R, TAOK2, CD27, AHSG, GRB14, IRS1, ENPP1, PTPRE, SOCS3, KCNQ1, KCNMB4, PPOX, SNCG, FEZ1, P2RX3, CALB1, DBN1, ARC, BCAN, BHLHE40, SYNGR1, CSPG5, NLGN2, CCL2, L1CAM, P2RX5, MAL, ELF1, RASGRP2, RGL1, RGL3, RALGDS, RASA2, ULK1, ATF1, ITGA2, HSP90AB1, MESP1
GO:0044243	Multicellular organismal catabolic process	0.000012	CST3, MMP1, MMP2, MMP3, MMP7, MMP9, MMP10, MMP13, MMP19, PRSS2, KLK6, CEL
GO:0030154	Cell differentiation	0.000072	DAB2, NKX2-5, FOXF1, MYO1C, SOX17, TGFBR2, TNNC1, SGPL1, CUL7, CYP24A1, FHL2, TAZ, WWOX, PAFAH1B1, NOTCH1, PSEN2, SOX2, SOX9, ATF1, LAMA5, NRTN, OVOL2, ZEB2, MDGA1, GFRA3, PAF1, PEX5, YWHAE, DCLK1, NTN1, HAND1, HGF, VEGFC, HSPG2, CHST11, TFCP2L1, GLI2, FST, MLF1, TP53, SOX4, CD24, SPN, DEAF1, RBP4, SPANXB2, HSPA2, PPP2R2B, STRBP, BBS4, NEURL, BAIAP2, AFG3L2, PIP5K1C, PARD6B, SEMA3A, UNC5B, GAS1, L1CAM, LMX1A, PLA2G10, NRP1, FEZ1, CELSR3, AMIGO1, EYA2, ADAM12, TBX2, DVL1, AGRN, MUSK, F2R, C1S, ACAT2, PPARG, ABCG1, HDAC5, NEFL, CHST3, NRG1, NAB2, SORT1, NTN4, SPN, LIF, HOXC10, ISL2, FOXA2, ROR1, ULK1, CHRNB2, EPHB3, PROP1, PCSK9, MESP1, PRDM12, CEBPA, TPO, THPO, EFNA1, NGRN, PIGT, PTPRR, SMARCA1, GAS7, NAPA, KLF6, BLNK, CDSN, SCEL, IL7R, TRIM10, DNASE2, EPAS1, ALAS2, ACIN1, MMP9, PLDN, CBFA2T3, SPINK5, ELF3, ALOX15B, VCAN, RXRA, GPRIN1, GNAO1, IL6, HGF, EFHD1, BMPR1B, PPL, SPRR1A, SPRR1B, TGM1, SHARPIN, PTHLH, GNGT1, CDKN1C, SMARCD3, DHRS2, MUM1, RELB, CD83, SPN, MAL, PSAP, PICK1, ERBB4, NEURL2, ACTG1, INSR, HINFP, MBNL1, PLG, INPP5D, CD27, TCFL5, KLK6, IAPP, WNT4, MAPK1, CLU, SOCS3, ENPP1, FNDC3B, AQP3, IL4R, RARA, MAFB, ETS1, ACVR2A, L3MBTL, TESC, MBNL3, IGFBP3, ATN1, PBX1, MIB1, NRP1, CCL5, BAX, PCSK4, SOX15, CTF1, NEUROD2, PTX3, FIG4, KLK8, CXADR, DTNBP1, CELSR2, FEZ1, MSI2, HOXD9, TBCE, MAG, ARHGEF1, DBN1, FABP4, ADRB2, LAMA3, ALDH6A1, TBX18, HRAS, KRAS, FOXO4, MORF4L2, OBSL1, CYP1A1, AHRR, ITGA2, SH2B3, CENPF, CSPG5, EID2B, EID2, DPYSL2, DUSP6, ATOH7, FHL1, AZI1, CADM1, NGEF, TMEM176B, CATSPER3, RHOB, STMN1, MAL, MDK, MMP19, ZBTB7B, ANGPTL4, SPATA6, PAQR5, CAND1, UNC45A, NDRG2, EDA2R, DMRTA1, GMCL1, BMP5, TLL2, BHLHE41, KAZALD1
GO:0048870	Cell motility	0.00023	CATSPER3, ATF1, LAMA5, NRTN, OVOL2, ZEB2, MDGA1, GFRA3, PAFAH1B1, PAF1, PEX5, YWHAE, DCLK1, NTN1, CD24, IL6, HGF, CCL2, ITGA2, MIA3, EDN2, MESP1, VEGFC, HDAC6, TACR1, THBS1, C5, ZFAND5, SGPL1, PLAU, TRIB1, IGFBP3, VAV3, PSG2, CEACAM1, TNS1, NRP1, TAOK2, ULK1, DNAJA1, ATP1A4, NEURL, LAMA3, LAMA3, PARD6B, NEXN, PDPN, ERBB4, F2R, F3, INSR, IRS1, MAPK1, IRS2, DLC1, ALOX15B, RNF20, ARAP3, IL1B, ITGB2, SAA1, SDS, COL5A1, PLG, GIPC1, CCL5, MSN, MMP9, BBS4, ARRB2, HDAC5, ETS1
GO:0006954	Infammatory response	0.0003	IL1A, IL1B, SPN, F2R, CD24, TACR1, F3, KLK3, CCL5, THBS1, PPARG, IL6, HGF, OSMR, GPX2, AHSG, F8, SIGIRR, SAA1, CFD, FHL1, C5, CLU, CD55, C1RL, C1R, C1S, C4BPB, PTGS2, ADRB2, FABP4, ITGA2, TGM2, HDAC5, TLR6, PDPN, MAL, LTB4R, S1PR3, ELF3, ALOX5, NCR3, XCR1, CXCL1, CXCL2, BLNK, HRH1, IL1RAP, ITGB2, OLR1, PTAFR, PTX3, RXRA, S100A8, CCL2, CCL21, BMPR1B, CXCR4, AFAP1L2, CHST1, PLA2G4C, PLAA, CHST2, CD40
GO:0016477	Cell migration	0.00055	ATF1, LAMA5, NRTN, OVOL2, ZEB2, MDGA1, GFRA3, PAFAH1B1, PAF1, PEX5, YWHAE, DCLK1, NTN1, CD24, IL6, HGF, CCL2, ITGA2, MIA3, EDN2, MESP1, VEGFC, HDAC6, TACR1, THBS1, C5, ZFAND5, SGPL1, PLAU, TRIB1, IGFBP3, ULK1, LAMA3, LAMA3, PARD6B, NEXN, PDPN, ERBB4, F2R, F3, INSR, IRS1, MAPK1, IRS2, DLC1, ALOX15B, RNF20, ARAP3, IL1B, ITGB2, SAA1, SDS, COL5A1, PLG, GIPC1, CCL5, MSN, MMP9, ARRB2, HDAC5, VAV3, PSG2, CEACAM1, TNS1, NRP1, TAOK2

GO, Gene Ontology.