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. 2015 May 7;12(2):2668–2676. doi: 10.3892/mmr.2015.3752

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Correlation between NRP1 and MMP2 expression in melanoma. (A) Positive correlation between NRP1 and MMP2 expression in melanoma. Melanomas which had high NRP1 expression also exhibited a significantly higher percentage of high MMP2 staining (n=365; P=0.02; χ² test). (B) and (C) Kaplan-Meier analysis of the correlation between concomitant NRP1 and MMP2 expression and overall (B) or disease-specific (C) 5-year survival of patients with melanoma (n=201; P=0.01 and P=0.03 respectively; log-rank test). NRP1, neuropilin 1; MMP2, matrix metalloproteinase 2.