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. 2015 Apr 14;12(2):1625–1630. doi: 10.3892/mmr.2015.3608

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Copyright © 2015, Spandidos Publications

This is an open-access article licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License. The article may be redistributed, reproduced, and reused for non-commercial purposes, provided the original source is properly cited.

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Ultrastructural alterations in synapses of hippocampal Cornu Ammonis 1 neurons in salicylate-treated animals. Representative images are shown at magnification, ×30,000. Transmission electron micrographs show that animals in the S10 group had a greater number of presynaptic vesicles (white arrows), thicker postsynaptic densities (black arrows), and greater synaptic interface curvature, as well as fewer microtubules and neurofilaments (arrowheads), than saline-injected control animals. S10, chronic salicylate treatment group; R#, number of recovery days.