Table I.

Synaptic parameters for the different experimental groups.

Synaptic parameters	Controls	S10	S10+R28
Vesicles (number/µm2)	5±3	73±24b	6±3
Cleft width (µm)	0.0083±0.0023	0.0088±0.0023	0.0082±0.0016
Postsynaptic density thickness (µm)	0.035±0.008	0.048±0.009a	0.038±0.011
Curvature	0.63±0.22	0.95±0.21a	0.68±0.26

Mean ± standard deviation for each parameter (n=18). The control group received daily intraperitoneal injections of saline for 10 consecutive days; the S10 group received daily intraperitoneal injections of salicylate (300 mg/kg) for 10 days; the S10+R28 group underwent identical treatment to that of the S10 animals, but were allowed to recover for 28 days before they were sacrificed for analysis.

^aP<0.05;

^bP<0.001 compared to control. S10, chronic salicylate treatment group; R#, number of recovery days.